Cell signalling / renal repair

Can patient-specific stem cell therapy enhance renal repair?

The advancement of stem cell biology has not only enhanced our understanding of organogenesis and tumourigenesis, but has also helped in designing stem cells as a therapeutic tool to accelerate tissue repair. Despite a complex array of genetic alterations needed for differentiation of pluripotent stem cells into a particular subset of cells, retroviral transduction of as little as three transcr...

The renal stem cell system in kidney repair and regeneration.

The adult mammalian renal tubular epithelium exists in a relatively quiescent to slowly replicating state, but has great potential for regenerative morphogenesis following severe ischemic or toxic injury. Kidney regeneration and repair occur through three cellular and molecular mechanisms: differentiation of the somatic stem cells, recruitment of circulating stem cells and, more importantly, pr...

Ubiquitin and SUMO signalling in DNA repair.

The repair of lesions and gaps in DNA follows different pathways, each mediated by specific proteins and complexes. Post-translational modifications in many of these proteins govern their activities and interactions, ultimately determining whether a particular pathway is followed. Prominent among these modifications are the addition of phosphate or ubiquitin (and ubiquitin-like) moieties that c...

Sarcomatoid Transrormation of Chromophobe Renal Cell Carcinoma

Perspectives in Pharmacology Mechanisms of Renal Cell Repair and Regeneration after Acute Renal Failure

In many cases, acute renal failure (ARF) is the result of proximal tubular cell injury and death and can arise in a variety of clinical situations, especially following renal ischemia and drug or toxicant exposure. Although much research has focused on the cellular events leading to ARF, less emphasis has been placed on the mechanisms of renal cell repair and regeneration, although ARF is rever...